Bacterial Pathogenesis
Tuesday 15 September 2009
BMB - 404506
Period: week 38 + 39
EC’s: 3
Course aims and content:
By covering the following topics students will get the opportunity to expand their knowlegde in the field of bacterial pathogenesis:
Bacterial Cell Biology
genome plasticity, mobile genetic elements, intracellular signaling, membrane biogenesis
Prokaryotic Cell Signalling
chemotaxis / mortility, cell-cell signaling (quorum sensing, biofilms)
Bacterial Virulence Strategies
LPS synthesis, carbohydrate receptors
Bacterial exploitation of host cell biology
Mucosal cell entry, transcytosis, intracellular trafficking and survival
Bacterial Community
Intestinal flora and health
Host Cell Defense
Innate receptors, innate effectors (collectins, defensins, sIgA, mucus)
Therapy & Resistance: mechanisms of action antibiotics, resistance mechanisms: integrons, plasmids, efflux pumps
- Bacterial related disease: chronic inflammation, atheroscleroris, auto-immuno diseases and tumor formation
During tutorials students will present and discuss the following topics: protein secretion systems, pathogenicity islands, bacterial adhesion, immune evasion strategies, novel antibiotics/phage therapy
Next to the written exam students are challenged to prepare an outline for their own PhD thesis. Handing in a sound plan will lead to an upgrading of the exam result.
Literature / study material used
Review articles
Useful other books
Schaechter’s Mechanisms of Microbial Disease
Prescott Microbiology
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